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In summary, intervertebral disc degeneration manifests as a comprehensive deterioration of the microenvironment, including increased ECM stiffness, reduced nutrients, increased acidity, hypoxia, and exacerbated inflammatory response

One-time screening for AATD is recommended by the World Health Organization for adults and their family members diagnosed with COPD

Materials and Methods The malignant phenotype of glioma was assessed by cell proliferation assay, colony formation assay, EdU assay, wound healing, and Transwell experiments