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The fat diet also altered the expression of genes controlling ovulation, luteinization and luteolysis ( Gm42508 genetic marker was nonetheless increased after high-fat feeding and was unaffected by DHA, which suggests a potential role in high fat diet-induced ovarian dysfunction ( in vitro maturation (IVM)

Although iron-dependent prolyl hydroxylases (PHDs) regulate both isoforms and iron chelation can stabilize HIF-1 and HIF-2 in vitro (74), these observations collectively suggest that the gut may implement additional, tissue-specific mechanisms that bias HIF isoform activity and downstream iron handling

Experts also highlight that scientific evidence supporting its skin-lightening effects remains inconsistent.