antioxidant glutathione synthesis protein Frontiers Glutathione Metabolism and Its Implications

Vizoso FJ, Eiro N, Cid S, et al

Although the pH of the contents within the stomach lumen of patients is typically highly acidic (pH1-3), the pH near the surface of the gastric epithelium measured in healthy patients is much more neutral (pH5-7) due to the presence of a protective mucous layer, bicarbonate secreted into this zone by epithelial cells, and the presence of mucosal blood flow, variables dependent on COX-1 mediated prostaglandin E2 production (Quigley & Turnberg, 1987)

In many in vivo disease studies or oxidative stress stimulation models, GPX1 deficiency enhances cell damage, apoptosis, and even leads to cell death

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