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One area that remains contentious in skin biology, as in other tissues, is the extent to which estrogen replacement can reverse detrimental changes that have already occurred and whether estrogen is beneficial in skin that is decades post menopause rather than in the perimenopause period

UV and visible light can break peptide bonds and reduce potency over time

Advertisement Research ArticleCell biologyNeuroscience Open Access | 10.1172/JCI165228 1 The First Affiliated Hospital of Jinan University, Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of the Chinese Ministry of Education, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, and The Sixth Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China

Bacteriostatic water and sterile water can be used in intravenous, intramuscular and subcutaneous injections