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Both are known precipitants that lower seizure threshold in susceptible individuals

Also, the cumulative need for colectomy after 10 years was 9.8%, nearly 50% of the patients were relapse-free in the last five years of the study, and only 20% of the patients with proctitis or left-sided disease progressed to pancolitis

Annu Rev Pharmacol Toxicol 53: 401-426

Environmental and behavioral factors also heavily influence outcomes: patients who developed durable habit changes during treatment (structured meal timing, exercise consistency, stress management) regain weight more slowly than those who relied entirely on medication's appetite suppression