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Both I3AA and I3PA are aryl hydrocarbon receptor (AHR) agonists 59 , which could activate AHR transcriptional activity and modulate inflammation in the gut 60,61,62,63 and brain 64,65

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Unlike chronic neurodegenerative diseases such as PD, AD, HD or ALS, which involve slowly progressive and multifactorial neuronal loss, stroke represents an acute insult where the timing of intervention is critical