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Nonetheless, the bioavailability and blood concentration remained low despite relatively high doses and short intervals between them

In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al

In addition, antioxidants have also been shown to be capable of reversing certain altered biochemical variables and this ability enhances its potential to provide for optimal therapeutic benefits while causing fewer or minimal side effects

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