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By supporting the production of healthy red blood cells, B12 injections can also help prevent or treat megaloblastic anemia - a condition where red blood cells are too large and unable to carry oxygen efficiently

In one key example, Hunter et al

Conditions associated with an MTHFR gene mutation The biggest concern with an MTHFR gene mutation is that you may be more at risk of developing homocysteinemia

This commenter further noted that the substantial clinical improvement criterion should be applied rigorously and that innovations should earn supplemental payment only if they offer a real patient-care advantage, not merely convenience