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Muscle-derived ROS positively regulate NF-B activation, acting as second messengers for TNF- [151], while the glutathione cycle negatively regulates this pathway [155]

Crimarco A, Springfield S, Petlura C, Streaty T, Cunanan K, Lee J, et al

We observed a shift to higher normalized theta values at 1 dpi in the geriatric samples compared to the young and old myogenic cells, suggesting an age-skewed cell cycle induction in early injury response that may represent a precocious activation phenotype