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The benefits of using lubricant for sexual activity can include reducing irritation and discomfort from friction such as rubbing or chafing, which can cause burning, pain, and tears, explains Christophers

Smoking and pollution exposure: Smoking and air pollution increase free radical production

To our knowledge there does not appear to be any diversion of sodium oxybate (GHB) from the licit to illicit market as has happened on such a large scale with other medications subject to abuse, such as methadone and oxycodone [192] both widely used for pain management [192, 193]

Certain liposomal transdermal systems may possess oily textures or necessitate certain application methods, potentially diminishing user convenience