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Phase 1 GLP-1 therapy Primary focus: Appetite regulation Weight reduction Blood sugar stabilization Phase 2 Recovery and rebuilding As GLP-1 dosing tapers or ends, attention may shift to rebuilding strength and metabolic resilience

Thangjam, G

Remaining challenges include variability of natural sources, limited pharmacokinetic and toxicological data, and hurdles in scale-up and standardization

GHRH pulses primarily determine the amplitude of GH secretory bursts by maintaining somatotroph GH synthesis capacity and directly stimulating release during permissive periods when somatostatin tone is low