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Thus, while upstream stem cells do have the ability to differentiate into diverse cell types, in ALS, stem cells therapies are now intended to secrete neurotrophic factors, differentiate into astrocytes and microglia, or synapse with diseased motor neurons (Table 6) [271]

In particular, vaginolysin [198], intermedilysin [198], and high glucose concentrations combined with pore-forming toxins [200] induce necroptosis of erythrocytes at concentrations that dont induce eryptosis