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Pfeilschifter J, Diel I, Pilz U, Brunotte K, Naumann A, Ziegler R: Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age

These symptoms occur because estrogen helps regulate the bodys internal temperature control system Estrogen plays a role in serotonin and melatonin production, which helps explain why sleep quality, mood, and cognitive clarity often decline as estrogen levels fall