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Table 1 Role of kinases in OR desensitization/tolerance

These effects can further reduce neuron damage and apoptosis

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mtROS-mediated oxidative damage results in cysteine residues within the mitochondrial calcium uniporter (MCU) becoming cysteinylated with S-glutathione, assembling the MCU channel into persistently active higher-order complexes, and promoting sustained mitochondrial calcium uptake [92]