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Thus, niclosamide, at relatively low concentrations, in only the tens of micromolar range, basically turns down the dimmer switch on the cells energy production while still preserving reversible viability (33)

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HGC-27 cells exhibit heightened sensitivity to erastin upon overexpression of cytoplasmic polyadenylation element binding protein 1 (CPEB1), which in turn reduces twist1 expression and activates the ATF4/ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) pathway [96]