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During the progression of MASH, the accumulation of lipotoxic and reactive oxygen species induce hepatocellular injury, inflammasome activation, release of proinflammatory chemokines with subsequent monocyte infiltration and activation of macrophages and hepatic stellate cells that drive steatohepatitis and hepatic fibrosis 2,3,4

Men with higher urinary BPA concentrations showed altered thyroid and reproductive hormone profiles, suggesting endocrine disruption at environmentally relevant exposure levels (64)

Here, we examined whether the Pellino3 protein, which has E3 ligase activity, is needed for APAP-induced liver injury and subsequently explored its molecular mechanism

The protocol consists of a pre-procedure regimen (7 days), requirements for the actual day of treatment, and a post-procedure regimen (2 weeks)