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A similar effect was observed when EAR-20 was applied alone after NMDAR stimulation with its natural agonists: the first EAR-20 application elicited a higher response compared to subsequent applications

h , Volcano plots of the fold change in mitochondrial metabolite abundance (log 2 ) versus P values (-log) from HEK-293T SLC25A39 knockout cell line expressing a vector control or SLC25A40 cDNA