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Highlights: Made in Japan, FDA-registered in both Japan and the Philippines, produced in ISO/GMP/HALAL-certified facilities

lactate, L-glutamate, and pyruvate, as their major carbon sources, and that the relative abundance of these carbon sources is different in the different host microenvironments relevant for meningococcal infection (nasopharynx, blood, cerebrospinal fluid, epithelial cells, endothelial cells, phagocytes) and subject to variation during meningococcal invasive disease