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Lancet (2015) 386(9996):91327

Biological half-life Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for the concentration of a biological substance, such as a medication, to decrease from its maximum initial concentration (C max ) to the half of C max in the blood plasma

The Tomas in vivo characterization in protein-restricted rats reported that IGF-I analogs that bind IGFBPs poorly including LR3-IGF-1 produce greater anabolic effects than equimolar native IGF-1 when administered by either continuous infusion or daily injection, with the differential most pronounced under injection conditions [2]