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5 A), indicating that these cells are undergoing a complex reactive transformation, characterized by ECM remodeling (MMP2, PCOLCE, LAMC2, ADAMTS19, ASPN, OGN, MFAP4, ANGPT2 and collagens COL6A3, COL12A1, COL28A1, COL2A1), cell adhesion, migration and astrocyte-ECM interactions (LOXL2, LAMC2), altered synaptic support and plasticity (WNT7A, LRRTM1, RELN, AGRN), neuroinflammatory signaling (TRIL), reduced regenerative capacity (GDF10, FGFR2) and decreased support to neuron integrity and survival (NDNF, COL2A1 and GDF10)

Change history 30 July 2025 This paper was originally published under Creative Commons Attribution 4.0 International license, CC-BY-NC-ND, The Author(s)

He X, Wu X, Chen R, Chen C, Liu X, Wu B, Huang Z (2016) Effectiveness of omega-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials