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Here are some of the most commonly reported patterns: Difficulty falling asleep, even when tired Waking in the early hours (typically between 2am and 4am) and being unable to get back to sleep Night sweats that disrupt sleep, sometimes multiple times per night Lighter, more fragmented sleep feeling like you never reach deep sleep Waking feeling unrefreshed, regardless of how many hours you've been in bed Increased anxiety or a sense of dread around bedtime Restless legs or an uncomfortable urge to move your legs at night Needing to use the bathroom more frequently during the night (nocturia) If you're experiencing one or more of these regularly, it's worth speaking to your GP or a menopause-informed healthcare provider

However, the opposite phenomenon is observed when NLRP1 activators are applied (182)

Most recent in vitro and in vivo (animal and human) studies were conducted with special attention paid to clinical conditions in which oxidative stress has been implicated

Psychiatry 60 , 142156 (1999)