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It plays a critical role in cellular energy production, DNA repair, and overall metabolic function

10.1053/j.gastro.2013.08.049 106 PanduranganA

ICD inducers can be categorized based on their immune induction mechanisms: Type I inducers primarily comprise genotoxic agents that lead to abnormal protein activation and DNA damage, while Type II inducers are generally more potent, inducing endoplasmic reticulum oxidative stress, perturbing ER homeostasis, raising intracellular Ca2+ levels, and rapidly activating danger signal pathways to expose and release DAMPs (137139)