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doi:10.1016/S0003-2697(03)00143-X

Consistent with the trends in the symptoms, we found that bumetanide had significant effects over the 3-month treatment course on both GABA/NAA ( F 1,41 = 5.06, fdr.perm.p = 0.0418) and GABA/Glx ( F 1,41 = 6.16, fdr.perm.p = 0.0418) ratios in the IC and GABA/Glx ratio ( F 1,48 = 5.47, fdr.perm.p = 0.0418) in the VC when considering baseline MRS measurements as additional covariates (Fig