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In short, in 96-well low-attachment U-bottom plates (Corning), we assembled (as described below) 1 h-HepOrg with 25 portal fibroblasts and 25, 50, 100 or 200 cholangiocytes, or with 100 cholangiocytes and 50 or 100 portal fibroblasts

Diabetic patients with NAFLD were included if they had been recently diagnosed with diabetes mellitus and did not use blood glucose-lowering medications

Many patients notice weight loss within the first few weeks, but significant results usually appear after several months of consistent use combined with lifestyle changes

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