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paracasei from MWKG led to distinct alterations in the expression patterns of genes associated with glucose regulation and lipid homeostasis in the hepatic tissues of treated mice

Abstract Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental health by exacerbating cognitive decline, functional disability, and comorbid chronic diseases

After equilibration was reached, N -ethylmaleimide (NEM, final concentration 40 mM) or iodoacetamide (final concentration 50 mM) were added and a second measurement loop was started

Consistent with the transcriptomic findings, proteomic analysis of liver from Gclc KO mice revealed that most significantly elevated proteins in Gclc KO liver were encoded by NRF2 target genes, including the canonical NRF2 target NQO1 (NAD(P)H Quinone Dehydrogenase 1) (Fig