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Additionally, a recent study revealed that caffeinated coffee enhances A 1 receptor density and function in the ventral, but not the dorsal, hippocampus of rats, suggesting that it is involved in processing mood-related information

Kypreos KE, Karagiannides I, Fotiadou EH, Karavia EA, Brinkmeier MS, Giakoumi SM, et al

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At the cellular level, stress-induced IL-6 activation leads to elevated reactive oxygen species (ROS) and inhibition of mitochondrial cytochrome c oxidase by nitric oxide