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This effect is also blocked by inhibitors of epidermal growth factor receptor (EGFR) and PI3K inhibitors, suggesting that the EGFR-PI3K pathway modulates PM 2.5 -induced MUC5AC expression ( Coordinated ciliary motion is important for the clearance of inhaled particles and irritants trapped in the mucus from the airways ( 2.5 exposure significantly aggravated ciliary deterioration and increased goblet cell hyperplasia in rabbits with chronic rhinosinusitis ( Figure 1 )