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Trayhurn, P

GSH is also the precursor of phytochelatins (PCs) and the substrate of glutathione S-transferase (GST), which plays an important role in the resistance of plants to heavy metal toxicity [15]

In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

This stands in contrast to the hepatotoxicity that terminated Pfizer's danuglipron and lotiglipron programs