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Future investigations will elucidate the molecular mechanism of glutamine addiction by identifying the death pathways activating during the impairment of glutamine catabolism or when glutamine is limited

Krzastek SC, Farhi J, Gray M, Smith RP

251 Notably, PHDs use iron, ascorbate, oxygen, and 2-oxoglutarate to hydroxylate and inhibit HIF1, while ROS disrupt these interactions, causing HIF1 accumulation