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Studies have shown that lactate can inhibit the polarization of M1 proinflammatory macrophages while promoting the polarization of M2 macrophages toward an anti-inflammatory and proangiogenic phenotype, with these effects being mediated through various mechanisms, including histone posttranslational modifications and signaling pathway regulation (107, 108)

doi: 10.1007/s00467-018-4157-2 97 NjeimRAlkhansaSFornoniA

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When growth hormone levels rise too high, somatostatin release increases to bring them back down