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Worth considering, the three research groups aforementioned used GABA doses that were logarithmically lower than most in vivo GABA protocols

10.1093/pcp/pcp079 Plant Cell Physiol

This approach was chosen because knockouts and knockdowns of XOR in LLC-PK1 cells were not viable, which was not unexpected given that mouse knockouts of XOR are lethal ( The observed reduction in XO and ALDH2 activity by GTN ( Figure 9 ) appears have an impact on several metabolic pathways, most notably purine metabolism ( Figure 5 )