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Packer, L., Witt, E

These metabolites have been implicated in BD disease activity, clinical manifestations, and inflammatory burden (82)

coli [199]

Crucially, in an LPS-induced mouse model of acute lung injury, treatment with compound 25L significantly alleviated pulmonary inflammatory infiltration and levels of pro-inflammatory cytokines (IL-1, IL-6, TNF-), providing direct pharmacological evidence supporting the hypothesis that P2Y14R inhibition alleviates lung inflammation (Ma et al., 2025)