glutathione synthetase deficiency acidosis

glutathione synthetase deficiency acidosis How Is Diagnosed? Frontiers | Case report: A

Name: glutathione synthetase deficiency acidosis How Is Diagnosed? Frontiers | Case report: A
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Frontiers Case report: A Chinese patient with glutathione synthetase deficiency and a novel glutathione synthase mutation Glutathione dysregulation and the etiology and progression of human diseases PMC Pyroglutamic acidosis Deranged Physiology Glutathione Participation in the Prevention of Cardiovascular Diseases

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Description

EMBO Mol Med

Since reduced glutathione has a half-life of around 9 hours at pH 7.5 in the absence of metals (Stevens et al., 1983) and multiple times faster in the presence of certain metals (Voegtlin et al., 1931), we wanted to exclude that GSH oxidizes over time in our assay, resulting in the formation of GSSG