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While aging causes a gradual decline of physiological functions, cellular senescence is defined as a state of permanent cell cycle arrest, accompanied by distinct metabolic activity (Kuilman et al., 2010

Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, et al

Herbal medicine for Hashimotos thyroiditis: A systematic review and network meta-analysis

In this scenario, it is argued that even if trypomastigotes are more dependent on glycolysis than oxidative phosphorylation for their energy need (Bringaud et al., 2009), they may still be exposed to excessive oxidative stress due to mitochondrial remodeling and increased ROS production (Gonalves et al., 2011)