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(2007) The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya

The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings

Higher Upfront Cost: While the cost per dose might be higher than oral supplements, the less frequent dosing schedule can sometimes balance out the expense over time