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This selective distribution indicates that ergothioneine acts primarily where oxidative damage is greatest

This attack leads to the activation of pro-apoptotic proteins like Bax while simultaneously suppressing anti-apoptotic factors such as Bcl-2, ultimately tilting the balance toward cellular demise

In the ischemia-reperfusion model of mice, compared with the wild type mice, the transgenic mice with super surface human Bcl-2 gene reduced the MI area and improved the ejection fraction (140)

The hydroxyl and hydroperoxyl radicals are the eponyms of a family of Reactive Oxygen Species (ROS), which disruptively react with biological structures, such as unsaturated lipids of cellular membranes, the backbone and bases of DNA and essential chemical groups of catalytic and signaling proteins