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The authors thank Prof Liwei An for manuscript editing and language polishing

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But if left untreated, it may cause the following symptoms: Weakness, tiredness, or lightheadedness Lack of energy A decline in your mental abilities, such as memory and focus A painful and red tongue (glossitis) Mouth ulcers Pins and needles (paraesthesia) Disturbed vision Irritability Causes of Vitamin B12 deficiency

160,161 As opioid agonists, furthermore, methadone and buprenorphine do not abort opioid tolerance or dependency so much as they offer safer, more sustainable and humane options for addiction maintenance than other opioid preparations