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Cardiac output is increased because of the positive inotropic and chronotropic effects of the drug in the face of diminished peripheral vascular resistance

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The co-administration of Irinotecan and GRA16 promoted the anti-cancer effects of Irinotecan by inhibiting NF-B and cell cycle arrest induced by GRA16, ultimately increasing the effectiveness of Irinotecan in treating non-small-cell lung carcinoma [176]