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The culture broth was subjected to liquidliquid extraction with EtOAc in a 1:2 ratio at room temperature, with stirring at 100 rpm for 72 h

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Alongside traditional therapies, these diseases have attracted interest for their potential to be treated with natural bioactive substances that have fewer toxic side effects

A study with an endoplasmic reticulum-associated protein (RTN1, Reticulon-1) focused on the inhibition of histone deacetylase (HDAC) enzymes has shown that the protein exhibits inhibitory activity only in the form of a copper complex (Nepravishta et al., 2009[324])