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The long-term effects of use are unknown, and the quality of products available outside of research settings may vary substantially

When the gland first becomes dysfunctional, symptoms might include: Dry skin Fatigue and lack of focus Feeling cold Constipation Weight gain Puffy, swollen-looking face Muscle weakness and trouble exercising What are the symptoms of thyroid problems in females

Long-term use of dopaminergic therapies like levodopa is often accompanied by wearing-off (end-of-dose) fluctuations and motor complications (5, 6)

Furthermore, targeted therapies are highly specific, and their success is largely dependent on the individual molecular characteristics of a patients cancer