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Inspection of heatmaps (produced with hierarchical clustering) revealed that expression of tagged wild-type FUS/TLS rescued the majority of splicing events that resulted from endogenous FUS/TLS reduction, yielding a pattern more similar to the parental cells (Fig

GLS is frequently overexpressed in various types of cancer, including TNBC, NSCLC, and acute myeloid leukemia ( Therefore, inhibiting Gln degradation by downregulating the expression of these enzymes may represent a novel strategy for cancer treatment

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Glutathione is important in the antioxidant defense, nutrient metabolism, and regulation of cellular events including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and protein glutathionylation ( de novo reduced glutathione ( Because cysteine contains sulfur, cysteine supports sulfur-dependent metabolism