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Description

Lieberman, A

Inhibition of protease activity has been shown to suppress tumor metastasis, with studies demonstrating that targeting the PI3K/Akt and JNK1/2 signaling pathways reduces MMP 2, MMP 9, urokinase plasminogen activator (u-PA), NF-B, and AP-1 mRNA and protein expression in tumor cells, thereby impeding tumor invasion and metastasis