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In fact, the loss of zinc from SOD1 results in the remaining copper in SOD1 becoming extremely toxic to motor neurons (Trumbull 2009)

Hepcidin, a peptide hormone that regulates systemic iron via FPN binding, can be delivered into the brain to reduce iron deposition and slow AD progression (329)

We further explored the mechanism of HBc degradation and found that the colchicineinduced reduction in HBc expression was markedly blocked by the autophagy inhibitors 3-MA, CQ, and especially BafA1 but not by MG132, which is a proteasome inhibitor (Fig