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As various matrix metalloproteinases are involved in the degradation of collagen and elastin, inhibition of these enzymes represents another strategy to prevent extracellular matrix breakdown and its influence on skin aging

Real time quantitative PCR Total RNA was obtained from 1.5 mL of aliquots from endpoints Z, A and B, using the QIAamp RNA Blood kit (Qiagen, Hilden, Germany), and cDNA synthesis was performed from 2 g of total RNA using the High-Capacity cDNA Reverse Transcription Kit (ThermoFisher, Waltham, Massachusetts), both according to manufacturers protocols

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Precision Engineered GHK-Cu (Copper Tripeptide-1) is a naturally occurring copper-binding tripeptide research compound available for research across Metro Manila and the Philippines, delivered as 50mg per pre-filled injection pen at 99% or higher purity