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A yeast two-hybrid (Y2H) screen using cytoplasmic or luminal fragment of TMEM106B for bait and a prey library derived from human adult brain has identified TMEM106C, the endocytic adaptor proteins, AP2M1 and CLTC, and the vacuolar protein sorting proteins, VPS11 and VPS13D as N-terminal TMEM106B-binding proteins, although the functional importance of these interactions remains to be determined [134]

One vial lasts 20 doses

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Male Wistar rats were divided into five groups: one control (untreated) and four NiCl 2 -treated groups, each receiving single oral dose of NiCl 2 at 45, 90, 135, and 180 mg/kg body weight