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The lack of standard diagnostic criteria for HT makes the diagnosis process subjective and does not cover the entire spectrum of the disease

C.CommandeurJ

In a clinical study involving patients with refractory SLEdefined as those with persistent disease activity despite high-dose glucocorticoids and/or cytotoxic drugsthe combination of Low-dose IL-2 (100 WIU, 35 days/month) and rapamycin(0.5 mg every other day) demonstrated synergistic effects (272)

1 Although N -acetylcysteine, a precursor of glutathione (GSH), is used for the treatment of APAP-induced liver injury at present, clinical efficacy is insufficient because of its narrow therapeutic window