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[DOI] [PMC free article] [PubMed] 441.Ius T, et al

26 This distinction has led to the integration of the IDH status into the WHO glioma classification

[35] The reaction begins with the nucleophilic attack by the C-2 carbanion on the carbonyl carbon of pyruvate, which has the oxidation state of an aldehyde, leading to the formation of a covalent bond between the coenzyme and pyruvate