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Management protocols may also be targeted at slowing disease progression or preventing recurrence

Similarly, after iron repletion, the E3 ubiquitin ligase HERC2 (HECT and RLD domain-containing E3 ubiquitin protein ligase 2) interacts with NCOA4 and induces its proteasomal degradation, rendering HERC2 a negative regulator of ferritinophagy[60]

The increasing oxidative stress and lipid peroxidation induce apoptosis and contribute to PQ toxicity (Bus et al., 1985

Moreover, vitamin C is required for synthesis of norepinephrine (3), and the mineral zinc is important for proper function of GABA, aspartate, and norepinephrine (12)