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-glucan-induced Mo can inhibit LPS-induced IRG1 expression, thereby blocking the detrimental effects of itaconate on immune tolerance (126) and increasing the expression of H3K27ac at the SDH level, restoring cellular metabolism (130), restoring the production of pro-inflammatory cytokines (131), and thereby reversing LPS-induced immune tolerance ( Figure 3 )

Fungal species and esophageal cancer In 2020, esophageal cancer led to an estimated 604,100 new cases and 544,076 deaths [1]

Its smaller molecular structure allows efficient diffusion in tissue models, facilitating localized cellular interactions