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Within the first week, many patients report a reduction in the background level of discomfort from chronic injuries

Neuroprotection means defending neurons against damage from oxidative stress, inflammation, excitotoxicity, and other threats

Inflammatory mediators, such as cytokines, regulate the function of the pineal gland, leading to the suppression (i.e., secretion of proinflammatory cytokines) or potentiation (i.e., secretion of glucocorticoids) of melatonin synthesis [67]

Johnson DA, Amirahmadi S, Ward C et al (2009) The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis